Logo
HOME
ABOUT US
CONTACT US
FAQ
Peptides

Humanin Dosage

what is humanin

Humanin is an endogenous peptide factor, better known as a mitochondrial derivative. It can consist of 21 or 24 amino acids, depending on whether it is synthesized in the mitochondria or the cytosol. This amino acid sequence shows many beneficial effects applied to diseases from various fields, including cardiovascular diseases, autoimmune diseases such as diabetes mellitus, and reproductive health conditions. Calming effects on various forms of anxiety and antineoplastic effects are just some of the potentially positive sides of this peptide. However, in addition to all of the above, the function that stands out the most is the cytoprotective property that has been most demonstrated on nervous tissue, so it is assumed that Humanin could save neuronal cells from death in Alzheimer's and other neurodegenerative diseases.

Dosage Chart

 

                  Timeline                  

  

During Brain Ischemia

  

Beginning of Reperfusion
 

 

Treatment of cardiac ischemia-reperfusion injury protocol

  

0.013mg/kg

(2 or 3 injections subcutaneously

total up to 0.04mg/kg)

  

 

0.04mg/kg 

(one subcutaneous injection)

About the Peptide

Humanin is a peptide known as a mitochondrial derivative, and this origin gives it an excellent basis for many further potential beneficial effects on the body. Its greatest advantage lies in its cytoprotective function. Therefore, the peptide may be able to protect cells from oxidative stress, which is most often caused by disrupting the defense systems against free oxygen radicals. This function has been further studied in nervous tissue and has achieved special results there.

Nervous tissue is still mainly unexplored, but it is assumed that this peptide, due to its neuroprotective effect, can save neuronal cells from various injuries caused by degenerative diseases such as Alzheimer's and Parkinson's diseases.

Another very important function is the potentially positive effect of Humanin on treating Diabetes Mellitus. Insulin resistance almost always precedes this disease, before patients develop type 2 of this disease. In this condition, insulin receptors are insensitive to this hormone, which further means that glucose does not enter the cells, and they are left without energy.

As a consequence of this, patients are always hungry despite the amount of food. It is believed that the mechanism of this condition may potentially be related to the Humanin levels, and numerous studies have shown that with the help of peptide therapy, the condition could be normalized.

Another scientific assumption was related to the connection between peptide levels and ischemic injury to various organs. When an organ does not receive enough blood for various reasons, this term is called ischemia. Cells suffer great oxidative stress and are exposed to high levels of free oxygen radicals, so the result of this condition could be a lack of nutrients and death.This occurs in myocardial infarction or stroke. In addition to the main therapeutic measure (surgery), studies have shown that Humanin therapy could potentially reduce cell death by apoptosis and improve their response to oxidative stress, thus increasing the chance of survival.

In addition to all of the above, the peptide also shows possible beneficial effects in treating macular degeneration and cardiovascular diseases, while scientists suggest that it may regulate reproductive health. The calming effect it has on anxious patients and its antineoplastic properties are some of the very useful functions that will be studied in the future.

humanin dosage facts

List of Uses for This Peptide

The Effect of Humanin on Neurodegenerative Diseases

Alzheimer's disease is a severe neurodegenerative disease whose main symptom is memory loss (it is a very common cause of dementia). Neurons suffer great neurotoxicity caused by various types of injuries, so their number is significantly reduced.

It has been believed that the action of mitochondria has a great influence on the treatment of these diseases and the improvement of the condition of neurons. Since Humanin is a mitochondrial derivative, scientists assumed that it can potentially increase the activity of these organelles and exert a neuroprotective function, which may be able to save neurons from apoptosis. Another disease where peptide has shown similar effects is Parkin's disease, a neurodegenerative disease with the main motor symptoms in the form of rigidity, instability, and various types of tremors. In cases of intracerebral hemorrhage, experimental studies have once again confirmed that therapy with this amino acid sequence could lead to the recovery of microglia (macrophages of brain tissue), which, after therapy, showed better activity against erythrocytes. When Humanin is injected exogenously, it could improve cognitive functions, and restore metabolic pathways.

Humanin's Connection to Reproductive Health and Insulin Resistance

Polycystic ovary syndrome (PCOS) is a common condition in women, especially during adolescence and puberty. Insulin resistance almost always occurs during this syndrome, and it is one of the three main symptoms (the other two are the appearance of pimples and irregular menstruation). In this case, a large number of micro cysts appear on the ovaries, which can sometimes disrupt the release of a mature egg into the fallopian tube and thus prevent fertilization, which sometimes even leads to infertility.

Insulin resistance is a condition before type 2 diabetes, so it is crucial to act in time before this metabolic disorder develops. In such cases, the receptors on the cells are not sensitive to insulin and since it is responsible for introducing glucose into the cells, it remains free in the blood vessels. Thus, the cells remain without energy and patients feel hungry, so they gain weight. Assumptions appeared that this disease could be linked to the levels of Humanin in the body.

Based on studies, it was determined that receptors for this peptide are present on several types of cells in ovaries, as well as in the follicular fluid. After the therapy, there was a significant drop in glucose levels and, therefore, insulin. An important result of the study is the fact that after the treatment the sensitivity of the receptors for this hormone increased, so the patients were no longer hungry and did not gain weight uncontrollably. Therefore, therapy with Humanin may be able to significantly improve the state of insulin resistance and, therefore, polycystic ovary syndrome.

The Impact of Humanin on Ischemia and Hypoxia

When an organ, due to a blockage of an artery or some type of bleeding, does not receive enough blood, the cells of that organ do not receive enough oxygen and glucose. This condition is called ischemia, and during it, cells are damaged by hypoxia and exposed to the uncontrolled effects of oxygen-free radicals, which is why they die in large numbers over time. Such conditions include myocardial infarction or stroke.

The first option is most often an intervention where, depending on the cause, an attempt is made to repair the damage. If it is bleeding, the doctor tries to find the source and stop it, while if the cause of ischemia is a blockage of an artery, the doctor attempts to free the blood path to the organ. However, even when the situation is resolved, and reperfusion (re-flow of blood to this organ) is established, it is also a big shock to the body. This is because while waiting for surgery, cells adapt to conditions without oxygen and switch to a different mode of action in anaerobic conditions, so reperfusion is a state of shock for the body. However, according to various studies, Humanin levels are associated with the rate of neuronal survival in such conditions. This peptide could potentially improve the static response to oxidative stress and prevent neuronal death by apoptosis. In addition, it also increases the amount of energy in the form of ATP molecules and metabolic activity. The aforementioned potential properties have been studied mostly on ganglion cells.

Dosage Calculator

Since Humanin has many indications, the dosage in which it is applied also depends on this. Unfortunately, there is still no protocol that is always followed, but the indication in the form of ischemic and reperfusion injury to the heart muscle is quite constant. During the ischemia itself, when the patient consults a doctor, Humanin is dosed with a total of 0.04mg/kg (in the form of 2 or 3 subcutaneous injections of 0.013mg/kg). Later, when the flow is re-established, the administration is most often carried out as a single subcutaneous injection of 0.04mg/kg. The dosage above must never be exceeded because serious side effects can occur. This therapy must be strictly controlled by a doctor and prescribed exclusively according to the indications.

Conclusion

As a mitochondrial derivative, Humanin is a peptide with many potentially beneficial effects. Some of the crucial ones are the possible contribution to the treatment of insulin resistance and diabetes mellitus type 2 within the framework of polycystic ovary syndrome, a positive effect on the survival of neurons during neurodegenerative diseases, as well as the survival of cells in reduced oxygen conditions during ischemia. If used in the mentioned dose according to the indications, this peptide could be a useful part of the therapy. Humanin will surely be part of wide-ranging research in the future.

More about Humanin peptide

Humanin - Side Effects

Humanin is a micropeptide, better known as a derivative of mitochondria. The fact that it originates from this organelle is crucial because this is where many benefits come from. If synthesized from the cytosol, it contains 24 amino acids, while the creation in the mitochondria determines the structure of 21 amino acids. Some of the significant properties show potential in treating Type 2 Diabetes mellitus, cardiovascular diseases, or conditions involving organ injury by hypoxia and ischemia.

Reproductive health is also a field of interest for Humanin because it may help in the therapy of polycystic ovary syndrome. Anxious patients can also benefit from this peptide because it has shown a possible calming effect on such cases, and scientific research is being conducted in the field of the antineoplastic effect of this peptide. However, in addition to all of the above, by far the best-known function of Humanin is cytoprotection, which specifically refers to nerve tissue. Scientists hypothesize that this amino acid sequence could help in the treatment of various neurodegenerative diseases, primarily Alzheimer's disease.

About the Peptide

Since Humanin is known for its origin in mitochondria (the organelle responsible for energy production in the cell), most of its beneficial effects are attributed to this specific source. Studies have shown that many autoimmune diseases arise due to impaired mitochondrial function, so the mechanism of action of this peptide is mainly based on the additional activation of this organelle. The most commonly highlighted cytoprotective function means that this peptide could protect the cell in various ways. This is most reflected in the improved static response to oxidative stress that occurs when too many oxygen radicals are released and attack the cells or the body's defense system against them is impaired. The most prominent results of this crucial function have been achieved in the field of nervous tissue. Specific in many ways, Humanin could protect neurons from apoptosis (targeted cell death) during many neurodegenerative diseases such as Alzheimer's disease, but also Parkinson's disease and intracerebral hemorrhage. As previously mentioned, it is believed that this peptide will, in the future, be part of the treatment for metabolic diseases such as Type 2 Diabetes.

However, the development of such a serious condition is always preceded by insulin resistance, when the insulin receptors on the cells are not sensitive to this hormone, which means that it cannot bring glucose and, therefore, energy into the cells. This is the reason why patients gain weight more because the previously ingested food is not converted into energy and they resort to taking additional food. It is very important to act immediately with a hygienic dietary regime and proper therapy so that a more serious disease does not develop from insulin resistance. Scientists have also discovered that high levels of Humanin could be linked to a higher survival rate of cells without enough oxygen. In such conditions, organs, for various reasons (closure of a blood vessel or bleeding), do not have enough blood and therefore no glucose and oxygen, so they suffer serious oxidative stress and are mostly destroyed. Even re-established blood flow (reperfusion) can be a shock to the body, but Humanin therapy has greatly helped save these cells, as confirmed by many scientific studies. Ischemia leads to infarction, which most often occurs with myocardium or in the case of stroke. Lesser known but very useful effects of this peptide are reflected in the potential treatment of macular degeneration, cardiovascular diseases, and anxiety, but also the field of reproductive health is a particularly important topic where serious progress has been made recently.

humanin side effects

READ MORE +