IGF-1 LR3 Dosage

IGF-1 LR3 is a recombinant synthetic peptide, an analogue of human insulin-like growth factor 1 (IGF-1). It consists of 83 amino acids, imitating its action with modifications that improve metabolic stability. Its main property is the potential effect on muscle growth and significant loss of fat deposits. In addition, the peptide may accelerate muscle recovery and show cognitive benefits such as improving memory and mood stabilization. Due to these functions, it is most widely used in the world of sports. It can also help in treating conditions characterized by a lack of growth hormone (as an analogue of the natural compound, it also releases growth factor). Activation of protein synthesis, improved cellular communication, and better glucose transport are just some of the beneficial effects that IGF-1 LR3 has on the body.

Dosage Chart

Timeline	1 – 4 weeks	4 – 6 weeks
Muscle volume and strength increase protocol	20 – 40mcg (subcutaneous injection once per day)	50 – 100mcg (divided into two subcutaneous injections per day)

About the Peptide

IGF-1 LR3 is an improved version and analogue of human insulin-like growth factor 1 (IGF-1). This natural compound is one of the main growth factors produced in the liver. When levels are low, the condition of dwarfism can develop. Therefore, there is an assumption that this peptide can help treat such a disease. One of the main properties is the glucose transport regulation and the activation of protein synthesis.

These effects are crucial for further muscle growth and increased strength because by regulating glycemia, the muscles are enriched with glycogen, and the increase in protein synthesis ensures volume gain. Additional secretion of growth hormone not only contributes to muscle growth but also improves cell communication through activated biochemical pathways essential for further linear development. IGF-1 LR3 may also be able to regulate the metabolism of various compounds and thus ensure that tissues receive a greater amount of nutrients, using them better. Due to its characteristics on muscle tissue, the peptide is most widely used in sports and bodybuilding.

In addition to this basic characteristic, the peptide can facilitate recovery after training and preparing the body for the next load. It works by increasing the growth hormone level, which accelerates the process of tissue growth and regeneration. Along with this nutritional supplement, it is also necessary to ensure proper sleep, because that is when the body performs all metabolic processes and restores the cell structures.

Used properly, this peptide can lead to improved cognitive performance. IGF-1 LR-3 may be particularly important as part of therapy in neurological conditions resulting from a lack of growth hormone. Additional synthesis can provide improved memory (in certain forms of dementia), increased concentration (ensuring attention), neuroprotective effects (in neurodegenerative diseases), and stabilization of mood.

The difference in chemical structure between this peptide and the original IGF-1 is the substitution of arginine at the third position, which significantly modifies the compound. It is continuously retained in the body, so its administration is limited to one or two subcutaneous injections. This property is provided by modifying the original protein binding capacity, which previously limited its retention in the body. The peptide is stable and provides its effects primarily by binding to muscle receptors.

The List of Uses

Muscle Growth

Muscle growth is an area of ​​interest for all athletes and bodybuilders. For this development process, it is necessary to physically tear muscle fibers (which happens during training) and then to incorporate proteins into these spaces (through nutrition and supplementation). This peptide could significantly accelerate and improve the process through two mechanisms. One of them is reflected in the mitogenesis, when new muscle fibers are created, available for tearing (training). This is crucial for athletes who have already achieved a certain level and have trouble with further progress. The second mechanism includes the development of hyperplasia (an increase in the number of muscle fibers). In addition to this action, the peptide improves protein synthesis and enables its incorporation into torn muscle fibers. The secretion of growth factors is also important, especially for those who otherwise have reduced levels of this hormone. Another property useful for muscle development is better nitrogen retention, which is important for achieving strength.

Fat Loss

Losing body fat is often necessary for health and aesthetic reasons. A common cause may be insulin resistance, a condition characterized by reduced sensitivity of insulin receptors, which prevents glucose from entering cells. Free and unused glucose is converted into fat over time through biochemical pathways and deposited subcutaneously. This peptide could increase the sensitivity of receptors, and thus, as a result, reduce body weight. In addition, IGF-1 LR3 may provide fat breakdown and speed up overall fluid metabolism. When glucose enters cells and converts into energy that the body uses as ATP molecules, cells often cannot distribute nutrients and take what they need. The peptide helps absorb and further utilize all nutrients, reducing the possibility of unnecessary fat deposition.

Improving Cognitive Performance

IGF-1 LR3 shows great potential for improving cognitive performance, especially in patients with low growth hormone levels, where these symptoms are more common. The peptide can potentially enhance memory, which may be useful in treating some types of dementia. It could also increase clarity and concentration, thereby increasing focus. The neuroprotective effect is perhaps the most significant because in neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease, it may save cells from deterioration induced by specific agents. In patients diagnosed with anxiety or bipolar disorder, it could stabilize mood and improve cognitive response to stress. The mechanism of action is reflected in enhanced activation of the sympathetic system, increasing the survival rate of neurons. It has been optimized and modified to achieve all the benefits with greater effect than the original IGF-1 molecule.

Dosage Calculator

The peptide dose varies depending on the indication. However, the most common application is in sports, when IGF-1 LR3 is used for muscle growth and strength. In this case, the peptide is administered in a dose of 20-40 mcg in the form of a subcutaneous injection once a day for the first four weeks. The dose can be increased to 50-100 mcg for the next two weeks, but only for advanced athletes. Then the dose is divided into two subcutaneous injections. After six weeks of use, taking an equally long break is necessary. If used once a day, it is best to use it after training, in the case of two doses, they can be divided into morning and evening. Before administration, it is mixed with bacteriostatic water in a certain ratio. For example, 1 mL of bacteriostatic water is added to 1 mg of peptide to obtain a solution of 1000 mcg/mL. This solution is stored in the refrigerator and is sufficient for 30 days of use. The injection is given subcutaneously in the abdominal area, but it can be given intramuscularly into the target muscle for a localized effect. The place can be varied to avoid reactions at the injection site.

Conclusion

IGF-1 LR3 is a synthetic analogue of natural human insulin-like growth factor 1. Imitating its action, many beneficial effects are achieved, the most important ones are muscle growth and strength, fat loss, rapid recovery, tissue regeneration, and improved cognition. If applied in the right dose according to the instructions, this peptide could be extremely useful in medicine and sports. IGF-1 LR3 will certainly be the subject of further research.

References:

1. Anderson, L. J., Tamayose, J. M., & Garcia, J. M. (2018). Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effects. Molecular and Cellular Endocrinology, 464, 65–74. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723243/
2. Yakar, S., & Adamo, M. L. (2012). Insulin-like growth factor 1 physiology: lessons from mouse models. Endocrinology and Metabolism Clinics of North America, 41(2), 231–247. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352546/
3. Ohlsson, C., Mohan, S., Sjögren, K., Tivesten, Å., Isgaard, J., Isaksson, O., Jansson, J. O., & Svensson, J. (2009). The role of liver-derived insulin-like growth factor-I. Endocrine Reviews, 30(5), 494–535. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754350/
4. LeRoith, D., & Yakar, S. (2007). Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1. Nature Clinical Practice Endocrinology & Metabolism, 3(3), 302–310. https://pubmed.ncbi.nlm.nih.gov/17315038/
5. Clemmons, D. R. (2007). Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer. Nature Reviews Drug Discovery, 6(10), 821–833. https://pubmed.ncbi.nlm.nih.gov/17906643/