Kisspeptin-10 Dosage

Kisspeptin-10 is a natural decapeptide produced in the hypothalamus of mammals. Its role is to actively stimulate the release of gonadotropin-releasing hormone (GnRH), which in turn causes the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary. The final stage reflects increased testosterone production naturally, which may be beneficial for men undergoing additional therapy with this hormone or to stop testicular atrophy. The original name of the peptide was Metastin due to suspicions that it could halt the further development of breast cancer and melanoma and act as a gene suppressor. Due to its characteristics, it is believed that it may be part of infertility therapy and increase sexual desire. Scientists assume it may also improve mood in patients diagnosed with anxiety or depression. Kisspeptin-10 also shows potential for preventing heart disease, improving immunity, reducing signs of aging, and accelerating brain function. There are various scientific studies suggesting that the peptide, due to its hormonal properties, could be used for specific diagnoses such as polycystic ovary syndrome, hypothalamic amenorrhea, or hypogonadism.

Dosage Calculator

Timeline	Starting Dose	Maintenance Dose
Protocol for treating testicular atrophy	100mcg (one subcutaneous injection in 2 or 3 weeks)	100 – 200mcg (one subcutaneous injection in 2 or 3 weeks)

About the Peptide

Kisspeptin-10 is a naturally synthesized decapeptide produced in the hypothalamus of mammals. The primary function from which many benefits arise is the active stimulation of Gonadotropin Releasing Hormone. This results in increased release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn leads to higher amounts of naturally secreted testosterone. These hormones are essential for reproductive health, and their regulation holds promise for treating various diseases. Kisspeptide-10 represents the minimal active sequence of Kisspeptin, thus realizing its full potential while causing very mild and rare side effects. It is composed of 10 amino acids, and its impact on GnRH is achieved by binding to the peptide receptor (KISS1R), acting as an agonist of G protein-coupled receptors. Stabilizing hormone levels is a benefit in itself because it prevents the development of hormonal diseases. Additionally, this regulatory property can be utilized as part of therapy for disorders related to the gonads, such as the ovaries and testicles.

Testicular atrophy in men is a condition where the testicles shrink in size and reduce function due to various infections, trauma, or medications. Since the testicles are the gonads that produce sperm necessary for fertilization, dysfunction can lead to sterility, decreased sex drive, and other symptoms. Scientific studies have shown that Kisspeptin-10 levels are associated with the development of this condition, and it is therefore assumed that therapy may be based on this peptide. Increased testosterone secretion may lead to the resolution of the problems that have arisen.

Kisspeptin-10 can naturally increase the secretion of LH hormone primarily by stimulating the secretion of GnRH. This way, the hormone may directly affect the restoration of homeostasis in female reproductive hormones and stabilize the menstrual cycle. This property significantly helps patients diagnosed with polycystic ovary syndrome in whom menstrual bleeding is irregular. As stated in the study results, most patients reported considerable improvement in menstrual regularity along with a better overall condition characterized by reduced bloating, acne, and pain at the beginning of their cycle.

Since the cause of most reproductive disorders lies in the disturbed secretion of hormones, this peptide can play a crucial role in treating other diseases, such as hypothalamic amenorrhea or hypogonadism. If brain function is affected, the question has arisen whether the peptide could reduce anxiety, improve mood, and enhance sexual desire. Patients diagnosed with anxiety experience outbursts of fear, mood swings, and sometimes panic attacks as a result.

Kisspeptin-10 can potentially be involved in the hormonal pathways responsible for creating a stress response by binding to receptors on the cell surface. In addition, it is assumed that it can influence the secretion of several neurochemicals responsible for the feeling of fear and inhibit them. This property makes this peptide one of the potentially leading compounds in stabilizing mood. Most patients who were included in clinical studies reported feeling an emotional balance and calmness, which was much more pronounced than before the application of peptide therapy. As a result, patients get a better stress response. In addition, they can feel a greater sexual desire, which is especially important for patients who were previously diagnosed with impotence.

List of Uses

Potential Therapy for Testicular Atrophy

Testicular atrophy is a reduction in the size of the testicles, but it can also include a decrease in function, which reflects lower testosterone production. As a result, sterility and infertility can occur. The causes of atrophy can be various bacterial and viral infections, trauma, vascular problems, conditions, or the use of harmful drugs. Symptoms are a visible decrease in the size of the testicles, reduced sexual desire, sterility, loss of muscle mass, or hair loss. Scientists believe that the occurrence of this condition may be linked to reduced levels of Kisspeptin-10.
Various scientific studies have confirmed this assumption, as most patients included in the studies had reduced levels of this peptide. However, after the administration of Kisspeptin-10, homeostasis was restored in most cases, and patients experienced a visible improvement.
Scientists assume that the peptide may stabilize hormonal responses by acting on the hypothalamic-pituitary-gonadal (HPG) feedback loop. This property is a key function because it operates through negative feedback.

This mechanism reacts when sufficient amounts of hormones are secreted, sending information back to the hypothalamus to stop further hormone synthesis. Due to this regulatory capability, the administration of the peptide enables the establishment of natural homeostasis. Kisspeptin-10 may potentially enhance sperm function, thereby increasing sperm motility and improving the chances of fertilization. Study results showed that fertile men had significantly higher concentrations of Kisspeptin-10 than those who were sterile.

Impact on Women's Reproductive Health

Female reproductive health directly depends on hormonal status. Any hormonal imbalance in the form of a jump or drop in the level of these compounds can result in the development of symptoms and the establishment of a diagnosis. By acting on GnRH and increasing its production, an increased synthesis of luteinizing (LH) and follicle-stimulating (FSH) hormone directly occurs. This property can be crucial, especially in patients who have low levels of LH hormone, because it can lead to the absence of menstruation, irregular cycles, or even sterility. The entire menstrual cycle is perfectly hormonally regulated, so even the slightest mistake in the timing of secretion or the amount of hormones can cause a problem.

Kisspeptin can regulate ovulation and thus improve the process of releasing a ready egg into the fallopian tube, where it prepares for fertilization. Thanks to the regulation of LH and FSH secretion, the release of mature and ready egg cells is ensured. This property can be an excellent basis for treating infertility in women if hormonal imbalance is the cause of the problem. By regulating these hormones, testosterone production is consequently regulated, and adequate spermatogenesis in the seminiferous tubules is ensured.

Impact on Brain Function

Kisspeptin-10 may be able to affect certain parts of the brain responsible for perceiving emotions, particularly stress. Therefore, it is assumed that it can be involved in treating anxiety and improving mood and sexual desire. Scientists believe that the mechanism of action lies in the inclusion of the peptide in the hormonal pathways responsible for emotions and the stress response. The primary mechanism of action is the modulation of serotonergic pathways. By interacting with them, the peptide can reduce the feeling of fear in patients with anxiety.
Additionally, it is possible to regulate the synthesis of certain neurochemicals, such as neurokinin B and dynorphin, which are essential for controlling and perceiving emotions. Scientific studies are increasingly suggesting that the peptide can affect the activity of glutamate and its receptors. As a result of the mechanisms above, increased sexual desire may also occur, which is especially important for patients diagnosed with impotence.

Dosage Calculator

The dosage is generally precisely defined but differs from indication to indication. Therapy should always start with a low dose, which in the case of testicular atrophy is 100mcg. It is administered as a subcutaneous injection with an insulin syringe, most often in the abdominal region. The maintenance dose is higher and is 100-200 mcg if necessary. Kisspeptin-10 is typically administered two or three times a week rather than daily. The dose must never be exceeded or changed independently, otherwise, side effects may occur.

Conclusion

Kisspeptin-10 is a natural decapeptide that stimulates the secretion of GnRH, thereby stimulating the secretion of LH, FSH, and testosterone. This mechanism may be a key element in treating testicular atrophy and many other conditions related to female reproductive health. Another significant effect is the possible impact on brain function. If dosed adequately at the beginning and during maintenance, this peptide can make a significant breakthrough in treating the conditions above. Regardless of achievements to date, Kisspeptin-10 will be the subject of future research.