PTD-DBM Dosage

PTD-DBM is a synthetic peptide that combines the properties of two separate components. The first is the Protein Transduction Domain (PTD), which consists of eleven amino acids. At the same time, there is another segment, the Disheveled Binding Motif (DBM), which consists of ten to fifteen amino acids. The primary function of this peptide is its beneficial effect on hair growth, which is achieved by stimulating the process of development in its key phases, as well as through the activation of papillary cells and other mechanisms. These effects make it highly effective in treating androgenic alopecia, diffuse telogen effluvium, and various skin lesions. In addition, scientists believe that this peptide is potent in skin regeneration, which makes it a leader in the development of aesthetic medicine and cosmetology. PTD-DBM can promote epidermal renewal and stimulate stem cells to differentiate, resulting in very beneficial properties.

Dosage Chart

About the Peptide

PTD-DBM is a synthetic peptide composed of approximately 25 amino acids and two separate components, which together stimulate hair growth and regeneration of connective tissue.
The Protein Transduction Domain (PTD) is the first component, consisting of eleven amino acids, and it plays a crucial role in transporting the peptide into the cell, where its effect will be exerted. On the other hand, the Disheveled Binding Motif (DBM) is the second component, consisting of ten to fifteen amino acids, and its primary function is to bind to Disheveled (Dvl). This special protein triggers the signaling pathway. This process triggers a series of cascading reactions, resulting in the activation of β-Catenin. When this protein appears in a cell, it influences the expression of various genes that lead to further differentiation of stem cells.

The most significant number of expressed genes is responsible for hair growth, which is the primary indication for using this peptide. It is assumed that PTD-DBM can have a stimulating effect on the process of hair growth from the root, especially in its crucial phases (anagen phase). Additionally, this peptide is considered potent in increasing the size and activity of the dermal papilla. As a result of therapy, patients experience rapid and sustained hair growth, with the hair becoming shinier, thicker, and of higher quality than before. Due to the effects above, scientific studies have shown it to be very effective in treating androgenic alopecia, diffuse telogen effluvium, as well as conditions where hair falls out as a result of chemotherapy, stress, or childbirth.

Thanks to the β-Catenin protein, which is activated upon entry into the cell, specific genes are expressed that affect the proliferation of keratinocytes and fibroblasts, as well as the synthesis of collagen. Scientists believe that, due to its effects on fibrous tissue and collagen synthesis, this peptide may have a beneficial impact on wound healing and tissue regeneration. This fact makes PTD-DBM a leading peptide in the development of aesthetic medicine and cosmetology. The great advantage of this peptide is that it does not disrupt the patient's hormonal status and produces long-lasting effects.

List of Uses

The Impact of PTD-DBM Peptide on Hair Follicle Formation and Repair

As hair grows, it undergoes different phases. In the first phase (anagen phase), hair growth is activated. In the second phase (regression), growth stops abruptly, while in the last (dormant phase), it falls out and eventually returns to the first phase.

However, there are certain conditions where this process becomes unbalanced, and the hair stops actively recovering and growing. The reasons can be various diagnoses, such as androgenic alopecia (when the hair is stuck in the telogen phase and does not return to the anagen one) or diffuse telogen effluvium (when the follicles are stuck in the resting phase but are reversible). On the other hand, the reasons for its occurrence can be postpartum conditions, stressful situations, chemotherapy, and many others.

Scientists assumed that PTD-DBM could affect hair growth by constantly returning the follicle from the resting phase to the initial phase. With the help of the PTD component, the peptide enters the cell and the nucleus, where it exerts its effect. Then, through the DBM component, it binds to Disheveled (Dvl), which further activates the β-Catenin signaling pathway. This crucial protein acts directly in the nucleus, affecting the expression of genes responsible for hair growth and renewal. This assumption has been confirmed through scientific studies, which show that patients diagnosed with alopecia and other scalp skin diseases generally report rapid hair growth, as well as thicker and higher-quality hair compared to their condition before therapy.

Beneficial Effect of PTD-DBM Peptides on Wound Healing

Once in the body, the peptide acts in the same way as it does in stimulating hair growth. The only difference is that β-Catenin works by activating the expression of genes responsible for the proliferation of keratinocytes and fibroblasts. Additionally, this peptide influences the synthesis of collagen and the extracellular matrix, thereby affecting the quality and quantity of connective tissue produced.

Due to these effects, the peptide is considered highly potent in stimulating wound growth and preventing scar formation. Instead of the reparative process (when the wound is filled with non-functional connective tissue), the peptide enhances the regeneration process (the wound is filled with functionally active tissue). This substance can be beneficial for superficial burns, acne, surgical scars, and post-laser wounds. The results of clinical studies in patients have shown accelerated wound healing and a reduced likelihood of scarring. Therapy with this peptide accelerates the wound healing process by 30 to 50 percent, with beneficial effects visible within a few weeks, and final results apparent in a few months.

Dosing Calculator

The dosage for each peptide therapy varies depending on the indication. When PTD-DBM is used in cases of alopecia and scalp conditions where hair growth needs to be stimulated, the dosage is specific. For the first two months, the peptide is used at a dose of 0.5 - 1mg/mL topically to the scalp once a week. This initial period, apart from its therapeutic importance, also plays a crucial role in the body's adaptation to the therapy itself. From the third to the sixth month, the peptide is applied in the same way and at the same dose, but the dosage is reduced to every ten to fifteen days. After the sixth month of therapy, PTD-DBM is administered at the same dose and in the same manner, but only as needed when symptoms recur.

Ways for topical application include using thin needles (microneedling), through a gel or serum, or via a mask. It is essential to follow the entire procedure in detail to achieve effective results.

Conclusion

PTD-DBM is a synthetic peptide that contains two separate components, the joint action of which achieves various beneficial effects. Some of them stimulate hair growth and improve its quality, as well as accelerate wound healing and reduce the chance of scarring. The maximum recommended dose of the peptide should never be exceeded or adjusted independently to prevent side effects. PTD-DBM will undoubtedly be the subject of further research.

References:

1. Choi S, Yoon M, Choi KY. Approaches for Regenerative Healing of Cutaneous Wound with an Emphasis on Strategies Activating the Wnt/β-Catenin Pathway. Adv Wound Care (New Rochelle). 2022 Feb;11(2):70-86. doi: 10.1089/wound.2020.1284. Epub 2021 Apr 20. PMID: 33573472; PMCID: PMC9831250.
2. Lee SH, Seo SH, Lee DH, Pi LQ, Lee WS, Choi KY. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis. J Invest Dermatol. 2017 Nov;137(11):2260-2269. doi: 10.1016/j.jid.2017.04.038. Epub 2017 Jun 6. PMID: 28595998. https://pubmed.ncbi.nlm.nih.gov/28595998/
3. Ryu YC, Lee DH, Shim J, Park J, Kim YR, Choi S, Bak SS, Sung YK, Lee SH, Choi KY. KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neogenesis. Br J Pharmacol. 2021 Jun;178(12):2533-2546. doi: 10.1111/bph.15438. Epub 2021 May 5. PMID: 33751552; PMCID: PMC8251890.