Selank Dosage

Are you stressed or on edge? You’re not alone. Millions of people around the world experience anxiety that prevents you from unwinding. The National Institute of Mental Health estimates that around 2.7% of adults in the United States live with Generalized Anxiety Disorder.

While traditional drugs are available, more and more people are turning to natural remedies. One alternative that scientists are exploring is Selank, an artificially created peptide that mimics substances found naturally in the body. Early signs show that it offers real benefits in calming anxiety, with fewer side effects of commercial drugs.

Selank Dosing Chart

About Selank

Selank is a short peptide initially created in Russia and used to help control anxiety while promoting cognitive function. It’s an artificial derivative of Tuftsin, a naturally occurring peptide that maintains control over the immune system. Tuftsin affects major factors such as IL-6, T helper cells, monoamine, neurotransmitters, and-brain-derived neurotrophic factor (BDNF), which are crucial to maintaining brain health and immune function.

Selank and Tuftsin are alike, although Selank has four additional amino acids. These ingredients help enhance the stability of the peptide and prolong its effects in the body. Researchers have experimented with Selank in clinical trials as a new treatment for generalized anxiety disorder.

Application of Selank

Clinical studies on depressed patients showed that Selank has the potential to reduce inflammation by inhibiting activity in a gene related to IL-6, which is an inflammatory cytokine. Selank is useful for patients with anxiety disorders with other accompanying symptoms like fatigue, tension, or even pain and palpitations of the nerves and heart.

Compared to typical anti-anxiety drugs such as benzodiazepines, Selank appears to ease other related symptoms of chronic pain and fatigue. This could be due to the fact that it is capable of interfering with IL-6 levels in the body, as well as possibly the way it is able to affect the metabolism of endogenously produced painkilling chemicals called enkephalins.

Animal studies show more clearly the mechanism of action of Selank. A study on rats showed that the peptide impacted the activity of over 30 genes involved in the inflammatory process of the body. Of all the studies conducted, this was one that offered a more detailed analysis of the complexity of Selank’s effect on the immune system.

Parts of the Selank peptide itself are useful. In mice, they regulate a variety of immune-related genes, including C3, Casp1, Il2rf, and Xcr1. Through these genes, Selank may be able to assist in bringing a better immune balance – and another reason why it could be useful for disorders where anxiety and the immune system interact.

Selank, Learning and Memory

Researchers have long found a connection between anxiety and memory. In most cases, as anxiety levels increase, so does the impairment of remembering or learning. While normal anxiety medications are able to correct this issue, Selank appears to push it further. Not only does it calm anxiety generally but has the ability to improve cognition on a direct level as well. In fact, more and more evidence points to the fact that Selank may actually enhance learning and memory on its own.

Experiments on rats that had been classically conditioned with food rewards and which were given saline or Selank afterward have had interesting results. The animals that received Selank showed increased stability of the trace memory, i.e., they retained information more effectively. This was regardless of whether the rats were stressed or not, indicating that Selank is able to support memory even when stress is not a prime factor to consider.

One reason for that could be the way that Selank treats gene expression in the hippocampus – the part of the brain responsible for learning and memory. Research shows that after nasal delivery of Selank, it alters expressions of 36 genes in this region. Many of those genes have to do with proteins on the cell membrane, which play an important role in ion flow-something critical to brain signaling and memory processes.

Although further studies need to be conducted to fully understand how Selank helps memory, these preliminary results show that it can help neurons to function in a way that makes learning and remembering easy.

Selank Dosage

Injections

Types of Injections
Subcutaneous (Sub-Q) Injections
It involves injecting slightly beneath the skin-most commonly in the stomach or thigh. It’s commonly referred to as one of the easiest forms of self-injection, allowing steady and gradual absorption into the body.

Intranasal Form (Non-Injection)
This method administers Selank through the nose and may offer a more direct effect on the nervous system. Effects do vary. If strictly seeking injections, Sub-Q or intramuscular (IM) administration would be more suitable.

Initial Dose

Low Range: 250-500 mcg per injection
Most people begin using a smaller dose to see how their body will react and cut the chance of side effects. Some inject daily, while others start out with two or three injections a week. The optimum frequency is generally based on individual goals and professional medical advice.

Maintenance Dose

Moderate Range: 500+1,000 mcg per injectionOnce a smaller dose is tolerated, some patients gradually increase their dose to the point where they want to experience more obvious effects. Regimens for maintenance can also vary-some inject daily, and others inject every other day or a few days per week in order to maintain the effects. Periodic break-up usage (or ’’cycling off’’) can also identify whether advantages like mental clarity or reduced anxiety last without continued use.

Frequency and Scheduling

Daily or Near Daily Use
This is a typical protocol for those requiring regular mood support, concentration, or overall cognitive function.

Short-Term Use
Others use a short course-every other-day or daily injections for a few weeks-to address acute stress or specific symptoms. Then they cycle off to assess if effects last without continued use.

Custom Plans
Finally, the best dosing regimen is based on your body’s individual reaction, your intent for taking Selank, and consultation with an experienced healthcare professional.

References:

1. Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neurosci Behav Physiol. 2003 Sep;33(7):639-43. https://pubmed.ncbi.nlm.nih.gov/14552529/
2. Kolik LG, Nadorova AV, Kozlovskaya MM. Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation. Bull Exp Biol Med. 2014 May;157(1):52-5. https://pubmed.ncbi.nlm.nih.gov/24913576/
3. Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016 Feb 18;7:31. doi: 10.3389/fphar.2016.00031. PMID: 26924987; PMCID: PMC4757669.
4. Zozulya AA, Kost NV, Yu Sokolov O, Gabaeva MV, Grivennikov IA, Andreeva LN, Zolotarev YA, Ivanov SV, Andryushchenko AV, Myasoedov NF, Smulevich AB. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull Exp Biol Med. 2001 Apr;131(4):315-7. doi: 10.1023/a:1017979514274. PMID: 11550013.
5. Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, Serebriakova EV, Siranchieva OA, Andriushenko AV, Telesheva ES, Siuniakov SA, Smulevich AB, Miasoedov NF, Seredenin SB. [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48. Russian. PMID: 18454096.
6. N.F. Mjasoedov et al, The Influence of Selank on the Parameters of the Hemostasis System, Lipid Profile, and Blood Sugar Level in the Course of Experimental Metabolic Syndrome. April 14, 2014.
7. Fridkin M, Stabinsky Y, Zakuth V, Spirer Z. Tuftsin and some analogs: synthesis and interaction with human polymorphonuclear leukocytes. Biochim Biophys Acta. 1977 Jan 24;496(1):203-11. https://pubmed.ncbi.nlm.nih.gov/576412/