Kisspeptin-10 Side Effects
Kisspeptin is a natural peptide composed of 10 amino acids produced in the hypothalamus. Its primary role is to stimulate the release of gonadotropin-releasing hormone (GnRH), which leads to an increase in the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The consequence of this hormonal regulation is a natural increase in testosterone levels, which is the primary basis for all the benefits of this peptide. Due to these properties, scientists assume that KIsspeptin -10 may be effective in treating testicular atrophy caused by various agents or even infertility in men and women. Increasing LH levels may regulate ovulation and the menstrual cycle.
Additionally, research suggests that this peptide may reduce the risk of heart disease, boost immunity, and slow the signs of aging. In patients diagnosed with anxiety or impotence, Kisspeptin may reduce feelings of fear and stabilize mood, along with an increase in sexual arousal. These properties suggest that the peptide may act on the brain and improve its function.
About the Kisspeptin-10 Peptide
Kisspeptine - 10 is a decapeptide naturally synthesized in the hypothalamus. Its primary role is to stimulate the production of GnRH, which further affects the increase and regulation of the secretion of LH and FSH. As a result, there is an increased amount of naturally secreted testosterone. The peptide achieves this effect by binding to the peptide receptor KISS1R, acting as an agonist of G protein-coupled receptors. In this way, the peptide regulates the hypothalamic-pituitary-gonadal (HPG) axis. The regulatory role itself is beneficial because it prevents the development of various reproductive system diseases while also maintaining health. Kisspeptide-10 is a minimal active sequence of Kisspeptin, which means that it achieves its full potential with a very low chance of serious side effects.
Increased testosterone levels can be an excellent basis for treating testicular atrophy in men. That is a condition of testicular shrinkage but also reduced function. That is why it is very often followed by infertility and potency problems. It can occur as a result of trauma, infection, and other agents.
The results of scientific studies indicate that most patients, after the administration of Kisspeptin 10, felt a significant improvement in their condition, the return of sexual desire, muscle mass gain, and increased fertility. It has also been proven that almost twice as much of this peptide is isolated from the blood of fertile men than from those who are sterile, which means that the level of Kisspeptin 10 is directly related to fertility.
As a result of stimulation of GnRH secretion, LH and FSH levels increase. This property is particularly important in patients with low levels of this hormone. They may experience a lack of menstruation, impaired ovulation, and problems with offspring. When the regulation of primarily LH but also FSH is established, regular bleeding is restored. The mature egg cell is ready to come out of the ovary into the fallopian tube at the right time every month and wait there for fertilization. This function can be crucial in the treatment of polycystic ovary syndrome, where girls generally have irregular cycles.
Kisspeptin-10 can act on specific parts of the brain, including hormonal pathways and the secretion of certain neurochemicals. In this way, the peptide improves the stress response, reducing feelings of fear and anxiety, which is an excellent basis for the therapy of depressive and anxious states. In addition, it can increase sexual desire and response to physical arousal. These properties prove the influence of the peptide on brain functions. The original name of the compound was Metastin for some time due to suspicions that it could stop the development of metastases and further progression of breast cancer and melanoma.
How it Works
The mechanism of action depends on the indication. Still, it is primarily based on the increased synthesis of GnRH, which leads to higher levels of LH and FSH and, consequently, to naturally higher testosterone levels. This property is crucial in treating testicular atrophy, a condition that is reflected in a decrease in the size of testicles and a reduction in their function. Since this is the sex gland in which sperm is produced, sterility can occur as a result of atrophy, along with loss of muscle mass, hair loss, or impotence. The causes of its occurrence can be various types of infections, aging, alcohol and drugs, medications, injuries, vascular problems, and many others.
Through scientific studies, it was initially assumed that the level of Kisspeptin -10 peptide may be related to fertility, a finding later confirmed. The double concentration of the peptide was found in the blood of fertile men compared to sterile ones.
Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are essential for female reproductive health. The primary effect of Kisspeptin-10 is to stimulate the synthesis of GnRH, which results in increased production of these two hormones. This regulatory property results in naturally increased levels of the sex hormone testosterone, which is essential for male reproductive health. LH and FSH are responsible for the entire menstrual cycle. An imbalance in the amount or timing of hormone secretion can significantly disrupt this balance and lead to the diagnosis.
In patients diagnosed with polycystic ovary syndrome, the main symptoms include amenorrhea, acne, and insulin resistance. Scientists assume that these symptoms are the result of hormonal dysregulation, and if not treated, they can have serious consequences such as difficulty conceiving or infertility. Clinical studies indicate that most patients included in the study experienced an improvement in symptoms and overall condition after receiving this peptide, primarily related to regular menstrual cycles. In this way, the egg cell becomes ready to leave the ovary and enter the fallopian tube, where it awaits fertilization. It is believed that the peptide may also be used to treat female infertility if the cause is hormonal.
Molecular Structure of Kisspeptin-10
The chemical formula of this compound consists of seventy-three carbon atoms, eighty-three hydrogen atoms, seventeen nitrogen atoms, and fourteen oxygen atoms. These atoms occupy a specific orientation in space and form the average molecular weight of the compound.
Side Effects
Symptoms of Poor Drug Tolerance
After the first few doses, symptoms of poor tolerance to the substance may occur in the form of nausea, vomiting, diarrhea, headache, or increased sweating. These effects are relatively common but typically short-lived and usually do not require any medical intervention. Kisspeptin - 10 can cause postural dizziness dependent on changes in position, as well as hot flashes. After the first few uses, these side effects should subside as the body adjusts to the compound. However, if any symptoms persist or worsen, patients are advised to consult a doctor.
Slow Food Processing Metabolism
Due to the hormonal regulation achieved by Kisspeptin 10, it has been determined that there may be a potential change in the metabolism of specific macronutrients. Any hormone therapy carries this side effect because even the return of hormone regulation still represents a change for the body. Patients included in the study reported a reduced desire to eat, a decrease in meal size, and a slower eating pace compared to their usual habits. This side effect is quite rare but can occur in the form of appetite suppression, which also results in reduced food intake. This side effect, when considered in isolation effect, could represent an excellent basis for addressing metabolic disorders. Most often, it does not require medical intervention. However, if it becomes serious, a change in dosage or the addition of another medication may be considered.
Injection Site Reactions
The method of application of Kisspeptin-10 includes, among other things, subcutaneous injections. In the first few times of application, side effects may occur at the injection site in the form of redness, swelling, or pain. These side effects are common, but they are short-lived and rarely require medical intervention. If any of the symptoms persist for an extended period or worsen, the patient is advised to consult a doctor immediately.
Safety
According to current research, Kisspeptin-10 is considered a safe compound when used as directed. The peptide should never be consumed without the advice of a doctor. In addition, the dosage should never be exceeded or changed frequently. Regardless of the knowledge gained so far, Kisspeptin-10 will undoubtedly be the subject of future research.